Diagnostic Anatomo-Pathologique du Cancer de la Prostate: Enquête Rétrospective

Abstract

Prostate cancer is a major public health concern due to its high prevalence among elderly men. This retrospective study was conducted in 2025 at the Specialized Hospital for Organ and Tissue Transplantation (EHS TOT) in Blida, involving a sample of 54 male patients diagnosed with this disease. These patients, mainly from Blida and neighbouring provinces (wilayas), were evaluated based on clinical, biological, radiological, and therapeutic data. The majority of patients (85%) were diagnosed between the ages of 60 and 80. The main observed risk factors included smoking (56%), consumption of red meat fatrich diets (33%), and sedentary lifestyles (22%). Urinary symptoms were reported in 78% of cases, while 22% were asymptomatic. PSA testing allowed for risk stratification: 37% of patients were classified as low risk (<10 ng/mL), 39% as intermediate risk (10–20 ng/mL), and 24% as high risk (>20 ng/mL). Imaging studies revealed disease extension in 22% of cases. All biopsies confirmed the presence of prostatic adenocarcinoma, with ISUP grades 1 and 2 (70%) being the most frequent, indicating less aggressive forms. According to the D’Amico risk classification, 66% of patients were intermediate risk. TNM staging showed that 69% had localized disease (T+N0M0). Treatments administered included radiohormonal therapy (67%), hormonal therapy alone (18%), and radical prostatectomy (15%). Patients with localized or locally advanced disease showed favourable 5-year outcomes, whereas all patients with metastatic disease died during the follow-up period. These findings clearly underscore the importance of early detection and stage-adapted management to improve prostate cancer prognosis