Vacuum drying of the Terbinafine HCl powder: A kinetics study and mathematical modeling

Abstract

warm optimization method DA-nlinfit. The second approach delivered predictions 3 times closer to actual measured residual moisture ratio MR. Accordingly, precise estimations are conveyed by the method in terms of Deff varying from (1.41 × 10–9 to 7.22 × 10–9) m2/s, Ea projected between (33.37 and 35.64) kJ/mol, and subsequently more accurate enthalpies ?H? (30.52;33.03)kJ/mol, entropies ?S?(-0.31;-0.29)kJ/K.mol and Gibbs free energies ?G?(136.77;126.58) kJ/mol. The qualitative analysis of the dry powder gives a better quality in the range [40 60] °C, but above this, the results are not satisfactory